Freitag, 03. Juni 2011

09.30 – 09.45h                     Welcome/ Introduction: Clemens A. Schmitt

Session I:     

09.45 – 11.00h                     Chair: Fabrizio d’Adda di Fagagna

09.45 – 10.15h                     Leonard Hayflick: A Brief History of the Discovery of the Relationship between Cell Senescence and Cancer

10.15 – 10.45h                     Jerry Shay: How Human Cells Bypass Telomere-associated Replicative Senescence In Cancer Development

10.45 – 11.00h                     Lars-Gunnar Larsson:  Cdk2 inhibition delays Myc driven leukemia in vivo through restoration of cellular senescence (Abstract Talk)

11.00 – 11.30h                     Coffee break


Session II:

11.30 – 12.45h                     Chair: Scott Lowe

11.30 – 12.00h                     Gerardo Ferbeyre: Regulation of E2F gene expression and senescence by the tumor suppressor PML

12.00 – 12.30h                     Masashi Narita: Gene expression in cellular senescence – from chromatin to proteins

12.30 – 12.45h                     Kristina Kirschner: Global analysis of tumour suppressor protein p53 shows plasticity in phenotype regulation (Abstract Talk)

12.45 – 14.15h                     Lunch/ Postersession


Session III:

14.15 – 16.00h                     Chair: Daniel Peeper                   

14.15 – 14.45h                     Oliver Bischof: Senescence is an Endogenous Trigger for microRNA-Directed Transcriptional Gene Silencing in Human Cells

14.45 – 15.15h                     Olivier Toussaint: Stress-induced premature senescence  

15.15 – 15.30h                     Maja Milanovic: Stem Cell-related Features in Therapy-Induced Senescence (Abstract Talk)

15.30 – 16.00h                     Manuel Serrano: Pancreatitis inhibits oncogene-induced senescence and promotes pancreatic cancer

16.00 – 16.30h                     Coffee break


Session IV:

17.15 – 18.30h                     Chair: Jerry Shay

17.15 – 17.45h                     Fabrizio D’Adda di Fagagna: Cellular Senescence is Imposed by Irreparable DNA Damage at Telomeres

17.45 – 18.00h                     Stéphane Ansieau: EMT-inducers override failsafe program induction and promote tumor initiation (Abstract Talk)          

18.00 – 18.30h                     David Tuveson: Controlling oncogenic Kras transformation


Samstag, 04. Juni 2011


Session V:

09.00 – 10.45h                     Chair: Jesus Gil

09.00 – 09.30h                     Peter Adams: Degeneration of the nuclear/cytoplasmic barrier and secretion of histones by senescent cells

09.30 – 10.00h                     Judith Campisi: The DNA damage response links senescence to chronic inflammation

10.00 – 10.15h                     Valery Krizhanovsky: The mechanisms of immune surveillance of senescent cells (Abstract Talk)

10.15 – 10.45h                     Igor Roninson: Transcriptional mechanism and pharmacological inhibition of the senescence-associated secretory phenotype

10.45 – 11.15h                     Coffee break

Session VI:  

11.15 – 12.30                       Chair: Judith Campisi

11.15 – 11.45h                     Jesus Gil: Regulation of p16INK4a expression by multiple homeobox proteins

11.45 – 12.15h                     Daniel Peeper: Senescence & Melanoma

12.15 – 12.30h                     Svenja Meierjohann: Myc controls melanocyte senescence by regulating intracellular cystathionase levels  (Abstract Talk)

12.30 – 13.30h                     Lunch/ Postersession


Session VII:

13.30 – 14.45h                     Chair: Manuel Serrano

13.30 – 14.00h                     Scott Lowe: Constructing and Deconstructing Cancer using Mouse Models and RNA Interference

14.00 – 14.30h                     Clemens A. Schmitt: Exploiting Metabolic Liabilities in Therapy-Induced Senescence

14.30 – 14.45h                     Jan Dörr: Therapy-inducible senescence controls lymphoma cell growth in vivo by paracrine senescence and adoptive immune mechanisms (Abstract Talk)

14.45 – 15.15h                     Coffee break


Session VIII:

15.15 – 16.30h                     Chair: Soyoung Lee

15.15 – 15.45h                     Florian Greten: Senescence in colonic tumor progression

15.45 – 16.00h                     Jelena Vjetrovic: Senescence secreted factors induce sensitization to TRAIL (Abstract Talk)

16.00 – 16.30h                     Lars Zender: Senescence Surveillance in Hepatocellular


16.30h                                   Final remarks 




Name Institution / Stadt
Peter Adams The Beatson Institute for Cancer Research, Glasgow (UK)
Oliver Bischof Institut Pasteur, Paris (F)
Judith Campisi The Buck Institute for Age Research, Berkeley (USA)
Fabrizio D'Adda di Fagagna IFOM Foundation - The FIRC Institute of
Molecular Oncology Foundation (I)
Gerardo Ferbeyre Faculty of Medicine, University of Montreal (CAN)
Jesus Gil Imperial College, London (UK)
Florian Greten Klinikum rechts der Isar der Technischen Universität München (D)
Leonard Hayflick University of California, San Francisco School of Medicine (USA)
Scott Lowe Cold Spring Harbor Laboratory (USA)
Masashi Narita Cancer Research UK Cambridge Research Institute (UK)
Daniel Peeper The Netherlands Cancer Institute, Amsterdam (NL)
Igor Roninson Senex Biotechnology, Inc., Columbia, SC (USA)
Clemens A. Schmitt Charité, Berlin; MDC, Berlin (D)
Manuel Serrano Spanish National Cancer Research Centre, Madrid (E)
Jerry Shay Medical Centre, University of Texas Southwestern, Dallas (USA)
Olivier Toussaint Research Unit on Cellular Biology, University of Namur (B)
David Tuveson Cancer Research UK Cambridge Research Institute (UK)
Lars Zender Helmholtz-Zentrum für Infektionsforschung, Braunschweig (D)