Group Blüthgen

Systems Biology of Molecular networks

Research Area

We are researching how cells process information about extra- and intracellular cues through the intra-cellular signalling and gene-regulatory networks. We mainly focus on pro-proliferative signalling pathways, where we aim to understand what design principles govern reliable information transfer and gene regulation and how oncogenic mutations change the properties of the signalling pathways. In particular we are interested how feedbacks within the signalling network may counteract drug action.

We are an interdisciplinary team of experimentalists and theoreticians and utilise mathematical models and theoretical concepts in order to analyse large- and medium-scale datasets on signalling and gene expression – a research approach which is known as systems biology.

If you are interested in our research area (e.g. for a internship, PhD or Postdoc position) please contact: nils.bluethgen(at)

Research Projects

Selected Publications

Blüthgen, N., Legewie, S., Kielbasa, S. M., Schramme, A., Tchernitsa, O., Keil, J., Solf, A., Vingron, M., Schäfer, R., Herzel, H. & Sers, C
A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.
FEBS J 2009; 276(4):1024-1035.
Legewie, S., Herzel, H., Westerhoff, H. V. & Blüthgen, N
Recurrent design patterns in the feedback regulation of the mammalian signalling network.
Mol Syst Biol 2008; 4:190.
Blüthgen, N. & Legewie, S
Systems analysis of MAPK signal transduction.
Essays Biochem 2008; 45:95-107.
Mrowka, R., Steege, A., Kaps, C., Herzel, H., Thiele, B. J., Persson, P. B. & Blüthgen, N
Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity.
Nucleic Acids Res 2007; 35(15):5120-9.
Bandapalli, O. R., Geheeb, M., Kobelt, D., Kuehnle, K., Elezkurtaj, S., Herrmann, J., Gressner, A. M., Weiskirchen, R., Beule, D., Blüthgen, N., Herzel, H., Franke, C. & Brand, K
Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases.
Int J Cancer 2006; 118(1):74-89.