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"Learning from the Yins and Yangs in Cancer"

May 24-25, 2019

Amano Rooftop Conference



Friday, May 24, 2019


Session I: DNA damage: tumor-protective or -promoting signaling?

09.30 – 10.00h              Welcome/ Introduction "The Yins and Yangs in Cancer" (Clemens A. Schmitt/Soyoung Lee)                                       

10.00 – 10.30h              Björn Schumacher: Genome instability in aging and cancer 

10.30 – 11.00h              Christian Reinhardt: Targeting defects in the DNA damage response for cancer therapy 

11.00 – 11.15h              Coffee break


Session II: Metabolic action - metabolic reaction

11.15 – 11.45h              Almut Schulze: Mevalonate pathway supports survival of p53 deficient cancer cells in metabolic restricted environments

11.45 – 12.15h              Tomer Shlomi: Cancer cellular metabolism at a spatial-temporal resolution

12.15 – 12.45h              Inbal Mor: Metabolic adaption to prolonged resource exhaustion 


12.45 – 14.30h              Lunch/Poster session


Session III: Resting cells - Re-initiating cells I

14.30 – 15.00h              Peter de Keizer: Targeting senescence against cancer and aging

15.00 – 15.30h              Raffaella di Micco: Dissecting the impact of cell senescence in the hematopoietic compartment

15.30 – 15.45h              Ismail Amr El-Shimy: Dissecting the effects of EGF starvation on EGFR signaling in the mouse small intestine using 3D organoid culture systems (Abstract talk)

15:45 – 16.00h              Cansu Yerinde: HDAC7 controls CD8+ T cell dependent anti-viral and anti-tumor immunity (Abstract talk)


16.00 – 16.30h              Coffee break


Session IV: Resting cells - Re-initiating cells II

16.30 – 17.00h              Clemens A. Schmitt: Awakening dormancy - the evil side of senescence

17.00 – 17.30h              Ulrike Stein: Cancer metastasis, linking senescence and stemness

17.30 – 17.45h              Özcan Cinar: Development of MyD88 L256 mutation-specific TCR gene therapy for treatment of B-cell lymphoma and leukemia (Abstract talk) 

17.45 – 18.00h              Maria Fernanda Lammoglia Cobo: Single cell identification of EBV epitope-specific T cell receptors for adoptive transfer against EBV infection and associated malignancies (Abstract talk) 


19.30h                          Speakers' Dinner


Saturday, May 25, 2019

Session V: Tipping the homeostatic balance

09.00 – 09.30h              Gaetano Gargiulo: On Yins, Yangs and Neoadjuvant targeted treatment in cancer

09.30 – 10.00h              Dorothy SipkinsThe yin and yang of leukemia cell metastases to the bone marrow: What goes in sometimes comes out

10.00 – 10.30h              Melanie Werner-Klein: Dissemination of genetically immature cancer cells: and then?


10.30 – 10.45h              Coffee break


Session VI: Tumor-promoting vs. tumor-suppressive inflammatory signaling 

10.45 – 11.15h              Andrea Ablasser: Targeting STING in senescence

11.15 – 11.45h              Jesus Gil: The senescence-associated secretory pathway (SASP), linking senescence cancer and inflammation

11.45 – 12.15h              Round table discussion: tumor-suppressive or -promoting? Killing or arresting cancer cells? Aging or renewal? Preventing or overtreatment? Stemness or differentiation?

                                     Debaters: selected speakers with vivid audience participation


12.15 – 13.00h               Lunch


Session VII: Tracking and tackling state and fate

13.00 – 13.30h               Rosalie Sears: Dynamic mechanisms controlling cell lineage plasticity and therapeutic resistance in pancreatic ductal adenocarcinoma

13.30 – 14.00h               Rune Linding: Deep decoding of network attacking mutations rewiring cancer

14.00 – 14.30h               Zeynep Altintas: NanoMIP applications in cancer diagnosis

14.30 – 14.45h               Final remarks


14.45 – 15.45h               Poster session and coffee