Das Bild zeigt rechts ein Trichterglas mit blauer Flüssigkeit und Glasstab zum Umrühren. Daneben steht ein Reagenzglasständer mit Reagenzgläsern, die ebenfalls blaue Flüssigkeit enthalten. Im Hintergrund ist ein Forscher zu sehen, der in der rechten Hand eine Pipette hält.

Program

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Program

"Learning from the Yins and Yangs in Cancer"

May 24-25, 2019

Amano Rooftop Conference

Berlin

 

Friday, May 24, 2019

 

Session I: DNA damage: tumor-protective or -promoting signaling?

09.30 – 10.00h              Welcome/ Introduction "The Yins and Yangs in Cancer" (Clemens A. Schmitt/Soyoung Lee)                                       

10.00 – 10.30h              Björn Schumacher: Genome instability in aging and cancer 

10.30 – 11.00h              Christian Reinhardt: Targeting defects in the DNA damage response for cancer therapy 

11.00 – 11.15h              Coffee break

 

Session II: Metabolic action - metabolic reaction

11.15 – 11.45h              Almut Schulze: Mevalonate pathway supports survival of p53 deficient cancer cells in metabolic restricted environments

11.45 – 12.15h              Tomer Shlomi: Cancer cellular metabolism at a spatial-temporal resolution

12.15 – 12.45h              Inbal Mor: Metabolic adaption to prolonged resource exhaustion 

 

12.45 – 14.30h              Lunch/Poster session

 

Session III: Resting cells - Re-initiating cells I

14.30 – 15.00h              Peter de Keizer: Targeting senescence against cancer and aging

15.00 – 15.30h              Raffaella di Micco: Dissecting the impact of cell senescence in the hematopoietic compartment

15.30 – 15.45h              Ismail Amr El-Shimy: Dissecting the effects of EGF starvation on EGFR signaling in the mouse small intestine using 3D organoid culture systems (Abstract talk)

15:45 – 16.00h              Cansu Yerinde: HDAC7 controls CD8+ T cell dependent anti-viral and anti-tumor immunity (Abstract talk)

 

16.00 – 16.30h              Coffee break

 

Session IV: Resting cells - Re-initiating cells II

16.30 – 17.00h              Clemens A. Schmitt: Awakening dormancy - the evil side of senescence

17.00 – 17.30h              Ulrike Stein: Cancer metastasis, linking senescence and stemness

17.30 – 17.45h              Özcan Cinar: Development of MyD88 L256 mutation-specific TCR gene therapy for treatment of B-cell lymphoma and leukemia (Abstract talk) 

17.45 – 18.00h              Maria Fernanda Lammoglia Cobo: Single cell identification of EBV epitope-specific T cell receptors for adoptive transfer against EBV infection and associated malignancies (Abstract talk) 

 

19.30h                          Speakers' Dinner

 

Saturday, May 25, 2019

Session V: Tipping the homeostatic balance

09.00 – 09.30h              Gaetano Gargiulo: On Yins, Yangs and Neoadjuvant targeted treatment in cancer

09.30 – 10.00h              Dorothy SipkinsThe yin and yang of leukemia cell metastases to the bone marrow: What goes in sometimes comes out

10.00 – 10.30h              Melanie Werner-Klein: Dissemination of genetically immature cancer cells: and then?

                                              

10.30 – 10.45h              Coffee break

 

Session VI: Tumor-promoting vs. tumor-suppressive inflammatory signaling 

10.45 – 11.15h              Andrea Ablasser: Targeting STING in senescence

11.15 – 11.45h              Jesus Gil: The senescence-associated secretory pathway (SASP), linking senescence cancer and inflammation

11.45 – 12.15h              Round table discussion: tumor-suppressive or -promoting? Killing or arresting cancer cells? Aging or renewal? Preventing or overtreatment? Stemness or differentiation?

                                     Debaters: selected speakers with vivid audience participation

 

12.15 – 13.00h               Lunch

 

Session VII: Tracking and tackling state and fate

13.00 – 13.30h               Rosalie Sears: Dynamic mechanisms controlling cell lineage plasticity and therapeutic resistance in pancreatic ductal adenocarcinoma

13.30 – 14.00h               Rune Linding: Deep decoding of network attacking mutations rewiring cancer

14.00 – 14.30h               Zeynep Altintas: NanoMIP applications in cancer diagnosis

14.30 – 14.45h               Final remarks

 

14.45 – 15.45h               Poster session and coffee