Programm

"Learning from the Yins and Yangs in Cancer"

24.+25. Mai 2019

Amano Rooftop Conference

Berlin

Freitag, 24. Mai 2019

Sitzung I: DNA damage: tumor-protective or -promoting signal

09.30 – 10.00 Uhr         Willkommen / Einführung (Clemens A. Schmitt/Soyoung Lee)

10.00 – 10.30 Uhr         Björn Schumacher: Genome stability in aging and cancer 

10.30 – 11.00 Uhr         Christian Reinhardt: Targeting defects in the DNA damage Response for cancer therapy

11.00 – 11.15 Uhr         Kaffeepause

Sitzung II: Metabolic action - metabolic reaction

11.15 – 11.45 Uhr          Almut Schulze: Mevalonate pathway supports survival of p53-deficient cancer cells in metabolically restricted environments 

11.45 – 12.15 Uhr          Thomer Shlomi: Cancer cellular metabolism at a spatial-temporal resolution

12.15 – 12.45 Uhr          Inbal Mor: Metabolic adaption to prolonged resource exhaustion

12.45 – 14.15 Uhr          Mittag / Poster

Sitzung III: Resting cells - Re-initiating cells I

14.30 – 15.00 Uhr         Peter de Keizer: Targeting senescence against cancer and aging

15.00 – 15.30 Uhr         Raffaella di Micco: Dissecting the impact of cell senescence in the hematopoietic compartment

15.30 – 15.45 Uhr         Ismail Amr El-Shimy: Dissecting the effect of EGF starvation on EGFR signaling in the mouse small intestine using 3D organoid culture systems (Abstract talk)

15.45 – 16.00 Uhr         Cansu Yerinde: HDAC7 controls CD8+ T cell dependent anti-viral and anti-tumor immunity (Abstract talk)

16.00 – 16.30 Uhr          Kaffeepause

Sitzung IV: Resting cells - Re-initiating cells II

16.30 – 17.00 Uhr         Clemens A. Schmitt: Awakening dormancy - the evil side of senescence

17.00 – 17.30 Uhr         Ulrike Stein: Cancer metastasis, linking senescence and stemness

17.30 – 17.45 Uhr         Özcan Cinar: Development of MyD88 L256P mutation-specific TCR gene therapy for treatment of B-cell lymphoma and leukemia (Abstract talk)

17.45 – 18.00 Uhr         Maria Fernanda Lammoglia Cobo: Single cell identification of EBV epitope-specific T cell receptors for adoptive transfer against EBV infection and associated malignancies (Abstract talk)

19.30 Uhr                     Abendessen (Speakers' Dinner)

Samstag, 25. Mai 2019

Sitzung V: Tipping the homeostatic balance

09.00 – 09.30 Uhr         Gaetano Gargiulo: On Yins, Yangs, and Neoadjuvant targeted treatment in cancer

09.30 – 10.00 Uhr         Dorothy Sipkins:The yin and yang of leukemia cell metastases to the bone marrow: What goes in sometimes comes out 

10.00 – 10.30 Uhr         Melanie Werner-Klein: Dissemination of genetically immature cancer cells: and then?

10.30 – 10.45h             Kaffeepause

Sitzung VI: Tumor-promoting vs. tumor-suppressive inflammatory signaling? 

10.45 – 11.15 Uhr         Andrea Ablasser: Targeting STING in senescence

11.15 – 11.45 Uhr         Jesus Gil: The senescence-associated secretory phenotype (SASP), linking senescence cancer and inflammation

11.45 – 12.15 Uhr         Round table discussion: tumor-suppressive or -promoting? Killing or arresting cancer cells? Aging or renewal? Preventing or overtreatment? Stemness or Differentiation?

                                    Debaters: selected speakers with vivid audience participation

12.15 – 13.00h              Mittag

Sitzung VII: Tracking and tackling state and fate

13.00 – 13.30 Uhr          Rosalie Sears: Dynamic mechanisms controlling cell lineage plasticity and therapeutic resistance in pancreatic ductal adenocarcinoma

13.30 – 14.00 Uhr          Rune Linding: Deep decoding of network attacking mutations rewiring cancer

14.00 – 14.30 Uhr          Zeyneb Altintas: NanoMIP applications in cancer diagnosis

14.30 – 14.45 Uhr          Abschluss

14.45 – 15:45 Uhr         Poster und Kaffee